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Details
Z-IL-CHO, a cell-permeable, reversible inhibitor, reduces amyloid β (Aβ)-production by blocking γ-secretase activity in vitro (Aβ₄₀ IC₅₀ = 7.9 µM; Aβ₄₂ IC₅₀ = 7.6 µM). Besides blocking the formation of Aβ the dipeptide aldehyde Z-IL-CHO also blocks the production of the γ-CTF (γ-secretase-generated carboxyl-terminal fragment), but does not affect the formation of amyloid-β-precursor protein (APP).
Catalog Number
N-1895
Molecular Formula
C₂₀H₃₀N₂O₄
Relative Molecular Mass
362.47
CAS Registry Number
[161710-10-7]
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Areas of Interest
Alzheimer's Disease
Links / Documents:
4048245
| Enzyme | Substrates | Inhibitors |
|---|---|---|
| γ-Secretase |
