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Details
Studies of the cellular effects of C-peptide have shown that it binds specifically in a nanomolar concentration range to a G-protein coupled membrane receptor, with subsequent activation of Ca²⁺-dependent intracellular signaling pathways. This resulted in stimulation of both Na⁺-K⁺-ATPase, and endothelial nitric oxide synthase activities. Administration of C-peptide to streptozotocin induced diabetic rats elicited a substantial increase in whole-body glucose turnover.
Catalog Number
H-6136
One Letter Code
EVEDPQVPQLELGGGPEAGDLQTLALEVARQ
Synonyms
Preproinsulin 1 (57-87) (rat), Insulin 1 Precursor (57-87) (rat), Proinsulin 1 (33-63) (rat)
Molecular Formula
C₁₄₀H₂₂₈N₃₈O₅₁
Relative Molecular Mass
3259.58
CAS Registry Number
41475-27-8
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Stimulator of glucose metabolization
Application
Diabetes
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