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Details
Intramolecularly quenched fluorescent substrate containing the ortho-aminobenzoyl (Abz) / N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor / acceptor pair. It mimicks the wild-type (JMV2235) β-amyloid precursor protein (βAPP) sequence targeted by β-secretase BACE (β-site APP-cleaving activity). This FRET substrate is cleaved by BACE1, BACE2, and cathepsin D.
Catalog Number
M-2560
Synonyms
Abz-APP₇₇₀ (669-674)-EDDnp, JMV2235
Molecular Formula
C₄₃H₆₂N₁₂O₁₅S
Relative Molecular Mass
1019.10
CAS Registry Number
1802078-43-8
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Alzheimer's Disease
Links / Documents:
Brochures:
Product citations
4045325
| Enzyme | Substrates | Inhibitors |
|---|---|---|
| β-Secretase |
