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4045325

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Abz-Amyloid β/A4 Protein Precursor₇₇₀ (669-674)-EDDnp trifluoroacetate salt
Abz-Val-Lys-Met-Asp-Ala-Glu-EDDnp trifluoroacetate salt

4045325

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price
4045325.0001 1 mg Request lead time  
CHF 137.00
CHF 127.41 (7%)

Details

Intramolecularly quenched fluorescent substrate containing the ortho-aminobenzoyl (Abz) / N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor / acceptor pair. It mimicks the wild-type (JMV2235) β-amyloid precursor protein (βAPP) sequence targeted by β-secretase BACE (β-site APP-cleaving activity). This FRET substrate is cleaved by BACE1, BACE2, and cathepsin D.
Catalog Number M-2560
Synonyms JMV2235, Abz-APP₇₇₀ (669-674)-EDDnp
Molecular Formula C₄₃H₆₂N₁₂O₁₅S
Relative Molecular Mass 1019.10
CAS Registry Number 1802078-43-8
Source Synthetic
Storage Conditions -20 ± 5 °C
Application Alzheimer's Disease
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Product citations

D.Andrau et al., J. Biol. Chem., 278, 25859 (2003)

4045325

Enzyme Substrates Inhibitors
β-Secretase