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Selective somatostatin receptor subtype sst4 agonist. In competitive radioligand displacement experiments using the non-selective radioligand ([¹²⁵I]-(Leu⁸,D-Trp²²,Tyr²⁵)-Somatostatin-28, YCFAWKTFC exhibited a high affinity for sst4 with an IC₅₀ value of 2.0 ± 0.5 nM. IC₅₀ values for sst1, sst2, sst3, and sst5 were >1000 nM, 622 ± 85 nM, 624 ± 213 nM, and 692 ± 166 nM, respectively. The nonapeptide YCFAWKTFC may serve as a lead compound or tool for preclinical and clinical studies.
Catalog Number
H-6092
One Letter Code
YCFAWKTFC
Molecular Formula
C₅₇H₇₁N₁₁O₁₂S₂
Relative Molecular Mass
1166.39
CAS Registry Number
[647016-22-6] net
Source
Synthetic
Storage Conditions
-20 ± 5 °C
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