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Details
PRL2915, Cpa-D-Cys-Pal-D-Trp-Lys-Tle-Cys-Nal-amide, highly potent human somatostatin subtype 2 receptor (hsst2) antagonist with a Ki of 12 nM. Ki values for the other subtypes were >1000 nM for hsst1, 100 ± 57 nM for hsst3, 895 nM for hsst4, and 520 nM for hsst5, respectively. No agonist activity was found when tested alone at concentrations up to 10 µM. In a rat pituitary growth hormone in vitro antagonist assay versus somatostatin-14 (1nM) the somatostatin octapeptide analog PRL2915 exhibited an IC₅₀ value of 1.8 nM.
Catalog Number
H-6056
Synonyms
PRL-2915
Molecular Formula
C₅₉H₇₁ClN₁₂O₈S₂
Relative Molecular Mass
1175.87
CAS Registry Number
[209006-18-8] net
Source
Synthetic
Storage Conditions
-20 ± 5 °C
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