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Amyloid β/A4 Protein Precursor₇₇₀ (586-595) (human, mouse, rat) trifluoroacetate salt
H-Ile-Ser-Tyr-Gly-Asn-Asp-Ala-Leu-Met-Pro-OH trifluoroacetate salt


Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4042598.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 105.00
CHF 97.65 (7%)
4042598.0005 5 mg Ships within 3-5 business days  
CHF 483.00
CHF 449.19 (7%)


Amyloid β/A4 Protein Precursor₇₇₀ (586-595) (human, mouse, rat) also known as APP-derived inhibitory peptide (APP-IP), efficiently inhibited the activity of gelatinase A (matrix metalloproteinase-2 (MMP-2)) (IC₅₀ = 30 nM), whereas its inhibitory activity towards membrane type 1-matrix metalloproteinase was much weaker (IC₅₀ = 2 µM). The decapeptide ISYGNDALMP had poor inhibitory activity towards gelatinase B, matrilysin or stromelysin (IC₅₀ > 10 µM). APP-IP is likely an active site-directed inhibitor of gelatinase A. Clarification of its mode of action might provide a lead for the design of novel anti-cancer drugs that block specific processes of tumor invasion and angiogenesis.
Catalog Number N-1850
One Letter Code ISYGNDALMP
Synonyms APP₇₇₀ (586-595) (human, mouse, rat), APP-IP
Molecular Formula C₄₇H₇₃N₁₁O₁₆S
Relative Molecular Mass 1080.23
CAS Registry Number [566173-30-6] net
Source Synthetic
Storage Conditions -20 ± 5 °C


Enzyme Substrates Inhibitors
Gelatinase A