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(Nle³⁵)-Amyloid β-Protein (1-40) ammonium salt
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Nle-Val-Gly-Gly-Val-Val-OH ammonium salt

4041778

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price
4041778.0500 0.5 mg Request lead time  
CHF 152.00
CHF 141.36 (7%)

Details

The reactive thioether of Met³⁵ is crucial for the activity of Aβ 1-40 and Aβ 1-42. Due to the replacement of Met by inert Nle, M35Nle Aβ 1-40 was no longer toxic to cultured hippocampal neurons and had little effect on the level of protein carbonyl residues. The Nle peptide showed the same propensity to aggregate, whereas sulfoxide formation hindered the required conformational transition from random coil to β-sheet.
Catalog Number H-7312
Synonyms (Nle³⁵) β-Amyloid (1-40)
Molecular Formula C₁₉₅H₂₉₇N₅₃O₅₈
Relative Molecular Mass 4311.83
CAS Registry Number 1802086-31-2
Source Synthetic
Storage Conditions -20 ± 5 °C
Application Alzheimer's Disease