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Details
High affinity ligand for all five somatostatin receptors (sst1-sst5). In AtT-20 mouse anterior pituitary tumor cells which mainly express sst2 and sst5 receptors the binding affinity of this somatostatin analog was found to be higher than that of somatostatin-14 (H-1490) and octreotide (H-5972). In a model of epileptogenesis, however, KE 108 did not exhibit antiepileptic activity suggesting that the high potency and efficacy of a synthetic ligand to all known somatostatin receptors may not reproduce entirely the effects of the natural ligand.
Catalog Number
H-6276
Synonyms
KE 108
Molecular Formula
C₆₇H₈₅N₁₅O₁₁
Relative Molecular Mass
1276.51
CAS Registry Number
496849-46-8
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Areas of Interest
Cancer Research
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