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Details
The Dutch mutation (E22Q) of amyloid β-peptide aggregates more readily than the wild-type peptide and the resulting fibrils show increased neurotoxicity. The mutant peptide E22Q induced apoptosis of cerebral endothelial cells at a concentration of 25 μm, whereas WT Aβ 1-40 and the Italian mutant E22K showed no effect.
Catalog Number
H-6696
APC Number
62-0-89
One Letter Code
DAEFRHDSGYEVHHQKLVFFAQDVGSNKGAIIGLMVGGVV
Synonyms
Amyloid β-Protein (1-40) Dutch Mutation, Amyloid β-Protein (1-40) E22Q, [Gln22] β-Amyloid (1-40)
Molecular Formula
C₁₉₄H₂₉₆N₅₄O₅₇S
Relative Molecular Mass
4328.88
CAS Registry Number
144410-00-4
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Alzheimer's Disease
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