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Details
Contrary to β-amyloid peptides mutated at position 22 (Dutch, Italian, Arctic mutants) the Flemish mutation (A21G) shows a decreased tendency to aggregate and a reduced neurotoxicity. In the studies of Betts and Tsubuki, A21G was degraded significantly more slowly by neprilysin than the wild-type Aβ 1-40 and the E22 mutants. The relative resistance to proteolytic degradation may account for the pathogenicity of the Aβ mutant.
Catalog Number
H-6702
APC Number
62-0-61
One Letter Code
DAEFRHDSGYEVHHQKLVFFGEDVGSNKGAIIGLMVGGVV
Synonyms
Amyloid β-Protein (1-40) Flemish Mutation, Amyloid β-Protein (1-40) A21G, [Gly21] β-Amyloid (1-40)
Molecular Formula
C₁₉₃H₂₉₃N₅₃O₅₈S
Relative Molecular Mass
4315.84
CAS Registry Number
154362-03-5
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Alzheimer's Disease
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