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Details
Cecropin P1 (SWLSKTAKKLENSAKKRISEGIAIAIQGGPR), a homolog of insect cecropins isolated from pig intestine, was thought to be the first mammalian antimicrobial peptide. Later studies showed that the peptide is produced by the intestinal parasitic nematode Ascaris suum. The 31 amino acid peptide is highly potent against Gram-negative bacteria but has a reduced activity against Gram-positive bacteria. A disruptive effect on bacterial membranes has been proposed as mechanism of antimicrobial activity.
Catalog Number
H-5718
APC Number
87-9-61
One Letter Code
SWLSKTAKKLENSAKKRISEGIAIAIQGGPR
Synonyms
Cecropin P1, porcine
Molecular Formula
C₁₄₇H₂₅₃N₄₅O₄₃
Relative Molecular Mass
3338.90
CAS Registry Number
125667-96-1
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Nematodic antimicrobial peptide
Application
Antimicrobial & Antiviral Peptides
Links / Documents:
Brochures:
Bachem product citations
M.Bacalum and M.Radu,
Int. J. Peptide Res. Ther.,
21,
47 (2015)
