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Details
Helodermin (exendin-2) was originally isolated from the venom of Gila monster (Heloderma suspectum). A high degree of sequence similarities to secretin, VIP, PHI, and GRF from mammal and bird was observed over the entire N-terminal (1-27) sequence. The isolation of helodermin was the first demonstration of the existence of a secretin/VIP-related peptide in an animal that is neither mammal nor bird. Among all known VIP-related peptides, helodermin was the most potent in stimulating cAMP production by NCI-H345 cell line.
Catalog Number
H-5696
APC Number
73-0-15
One Letter Code
HSDAIFTQQYSKLLAKLALQKYLASILGSRTSPPP-NH₂
Molecular Formula
C₁₇₆H₂₈₅N₄₇O₄₉
Relative Molecular Mass
3843.49
CAS Registry Number
[89468-62-2]
Source
Synthetic
Storage Conditions
-20 ± 5 °C
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