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Details
Specific fluorogenic (FRET) substrate for collagenase-3 (MMP-13) with a kcat/Km value of 1.09 · 10⁶ M⁻¹s⁻¹ (pH = 7.5, T = 25 °C, substrate concentrations: 0.7 and 1.4 µM (S << Km), determined for activated recombinant collagenase-3). Collagenase-3 hydrolyzed Mca-Pro-Cha-Gly-Nva-His-Ala-Dpa-amide 70 - 100 fold more efficiently than collagenase-2 (MMP-8) and collagenase-1 (MMP-1).
Catalog Number
M-2515
APC Number
76-4-82
One Letter Code
Mca-P-Cha-AG-Nva-HA-Dpa-NH₂
Synonyms
MMP-13 Substrate, Fluorogenic
Molecular Formula
C₅₁H₆₅N₁₃O₁₅
Relative Molecular Mass
1100.16
CAS Registry Number
[256394-94-2] net
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
MMP-13 substrate
Areas of Interest
Cancer Research
Inflammation Research
Inflammation Research
Links / Documents:
Brochures:
Bachem product citations
4038444
| Enzyme | Substrates | Inhibitors |
|---|---|---|
| Collagenase-3 | ||
| Matrix Metalloproteinase-13 (MMP-13) |
