Myristoyl-(Lys¹²·²⁷·²⁸)-VIP-Gly-Gly-Thr (free acid) 4037992

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Myristoyl-(Lys¹²·²⁷·²⁸)-VIP-Gly-Gly-Thr (free acid) trifluoroacetate salt
Myristoyl-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Lys-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Lys-Lys-Gly-Gly-Thr-OH trifluoroacetate salt

4037992

Product No.	Pack Size	Available	ADS InfoAnalytical Data Sheet	List Price	Online Order Price	Qty
4037992.0500	0.5 mg	Ships within 1 business day	ADSExemplary Data Sheet of a current available lot.	CHF 265.00	CHF 246.45 (7%)
4037992.1000	1 mg	Ships within 1 business day	ADSExemplary Data Sheet of a current available lot.	CHF 459.00	CHF 426.87 (7%)

Details

PG 99-465 is a high affinity, selective VPAC2 receptor antagonist. It exhibited a 100-fold preference for the VPAC2 over the VPAC1 receptor. The compound showed partial agonistic activity on the VPAC1 receptor and was inactive on the VPAC2 receptor transfected in CHO cells, as well as on naturally expressed human VPAC2 receptors in the SUP T1 cell line.
Dickson et al. observed an agonistic effect of PG99-465 on the human VPAC1 and PAC1 receptors. When applied singly, PG99-465 increased [cAMP](i) at all three hVPAC/PAC receptor subtypes.

Catalog Number H-7292

Synonyms PG 99-465

Molecular Formula C₁₇₁H₂₈₃N₄₅O₄₇S

Relative Molecular Mass 3753.47

Source Synthetic

Storage Conditions -20 ± 5 °C

Areas of Interest Cancer Research

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