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Details
PG 99-465 is a high affinity, selective VPAC2 receptor antagonist. It exhibited a 100-fold preference for the VPAC2 over the VPAC1 receptor. The compound showed partial agonistic activity on the VPAC1 receptor and was inactive on the VPAC2 receptor transfected in CHO cells, as well as on naturally expressed human VPAC2 receptors in the SUP T1 cell line.
Dickson et al. observed an agonistic effect of PG99-465 on the human VPAC1 and PAC1 receptors. When applied singly, PG99-465 increased [cAMP](i) at all three hVPAC/PAC receptor subtypes.
Catalog Number
H-7292
Synonyms
PG 99-465
Molecular Formula
C₁₇₁H₂₈₃N₄₅O₄₇S
Relative Molecular Mass
3753.47
CAS Registry Number
2243219-86-3
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Cancer Research
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