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4037661

Availability: In stock

(Pyr¹¹)-Amyloid β-Protein (11-40)
Pyr-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH

4037661

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4037661.0500 0.5 mg Ships within 3-5 business days  
CHF 105.00
CHF 97.65 (7%)
4037661.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 185.00
CHF 172.05 (7%)

Details

pEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV, the N-terminally truncated isoform of the amyloid β-protein (Aβ) beginning with a pyroglutamate (Pyr) residue at position 11 was used in experiments studying the generality of fibrillogenesis-related helix formation. Comparing the fibrillogenesis kinetics of many of the most important clinically relevant amyloid β-protein alloforms it could be observed that among these peptides (Pyr¹¹)-amyloid β-protein (11-40) exhibited the greatest retardation of fibrillization rate.
Catalog Number H-6382
One Letter Code pEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Molecular Formula C₁₄₃H₂₂₆N₃₈O₃₉S
Relative Molecular Mass 3133.67
CAS Registry Number 192377-94-9
Source Synthetic
Storage Conditions -20 ± 5 °C
Application Alzheimer's Disease
Links / Documents:
Brochures:

Bachem product citations

K.Tanabe et al., Chemical Science, 5, 2747 (2014)

Product citations

R.Perez-Garmendia and G.Gevorkian, Curr. Neuropharmacol., 11, 491 (2013)
M.D.Kirkitadze et al., J. Mol. Biol., 312, 1103 (2001)
S.S.Mok et al., J. Neurosci. Res., 61, 449 (2000)
W.He and C.J.Barrow, Biochemistry, 38, 10871 (1999)
C.Russo et al., FEBS Lett., 409, 411 (1997)