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Details
Glucagon-Like Peptide 1 (GLP-1) is synthesized by posttranslational processing of proglucagon in the intestine and pancreas and plays an important role in metabolic homeostasis. Among the different molecular forms, such as GLP-1 (7-36) amide and GLP-1 (7-37), the function of GLP-1 (1-37) has been unclear. GLP-1 (1-37) was shown to convert intestinal epithelial cells into insulin-producing cells. These observations turned GLP-1 (1-37) into a new promising therapeutic compound for the treatment of diabetes mellitus.
In animal models of dilated cardiomyopathy, hypertensive heart failure, and myocardial infarction, GLP-1 has shown a remarkable cardioprotective activity.
Catalog Number
H-5552
APC Number
46-1-11
One Letter Code
HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG
Synonyms
Proglucagon (72-108) (human, bovine, guinea pig, mouse, rat), Glucagon-Like Peptide 1 (1-37) (human, bovine, guinea pig, mouse, rat), Preproglucagon (92-128) (human, bovine, guinea pig, mouse, rat)
Molecular Formula
C₁₈₆H₂₇₅N₅₁O₅₉
Relative Molecular Mass
4169.54
CAS Registry Number
87805-34-3
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Insulinotropic hormone; Incretin
Application
Diabetes
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