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Details
Neuromedin U is a neuropeptide which is widely distributed in the gut and central nervous system. Initially isolated from porcine spinal cord it was named for its uterine contractile activity. In fasted rats neuromedin U expression in certain brain areas is lower than in fed rats. In animal studies with neuromedin-23 (rat) overnight food intake is significantly reduced indicating that neuromedin U may be a physiological regulator of food intake. IC₅₀ values for the binding of neuromedin U-25 (human) to the human neuromedin U receptors NMU1R and NMU2R are 2.7 nM and 1.8 nM, respectively.
Catalog Number
H-5538
APC Number
62-0-54
One Letter Code
FRVDEEFQSPFASQSRGYFLFRPRN-NH₂
Synonyms
NMU-25 (human)
Molecular Formula
C₁₄₁H₂₀₃N₄₁O₃₈
Relative Molecular Mass
3080.42
CAS Registry Number
312306-89-1
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Obesity Research
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