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Details
This decapeptide resides within the first extracellular domain (EC1) of N-cadherin. It inhibits cadherin-mediated cell adhesion, compaction of eight-cell-stage mouse embryos and rat neurite outgrowth on astrocytes. In the presence of this peptide Ca²⁺-dependent cell aggregation of bovine brain microvessel endothelial cells is prevented. A putative application in creating channels for paracellular drug delivery across blood brain barriers has been proposed.
Catalog Number
H-5492
APC Number
79-1-20
One Letter Code
LRAHAVDVNG-NH₂
Synonyms
Cadherin-1 (76-85) amide (chicken), N-Cadherin (76-85) amide (chicken), Cadherin Peptide, avian
Molecular Formula
C₄₄H₇₅N₁₇O₁₃
Relative Molecular Mass
1050.19
CAS Registry Number
[127650-08-2]
Source
Synthetic
Storage Conditions
-20 ± 5 °C
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