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Details
Aspartimide formation of the highly base-labile Asp-Gly motif during Fmoc-SPPS may be completely suppressed by coupling this Hmb-protected dipeptide derivative. Additionally, Hmb prevents aggregation of the growing peptide chain as efficiently as the incorporation of a pseudoproline moiety. O-Acylation renders the Hmb moiety acid-stable facilitating the purification of peptides prone to form aggregates. The acyl group can be removed with hydrazine hydrate in DMF (cf. Quibell).
Catalog Number
B-3650
Synonyms
Fmoc-Asp(OtBu)-N-(2-hydroxy-4-methoxy-Bzl)-Gly-OH
Molecular Formula
C₃₃H₃₆N₂O₉
Relative Molecular Mass
604.67
CAS Registry Number
502640-94-0
Storage Conditions
-20 ± 5 °C
Keywords
Dipeptide building block
Links / Documents:
Brochures:
Product citations
M.Quibell et al.,
J. Chem. Soc., Perkin Trans. I,
2019 (1995)
