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Details
α-CGRP (8-37), a competitive CGRP1 receptor antagonist, exhibited hypothermic and antinociceptive effects. CGRP-I (8-37) antagonized the effects of amylin and amylin (1-8) on osteoblasts but was substantially less potent in this regard than amylin (8-37). Furthermore, it inhibited the evoked discharge frequency of wide dynamic range neurons in dorsal horn of the spinal cord in rats.
Catalog Number
H-4924
APC Number
22-5-18
One Letter Code
VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH₂
Synonyms
CGRP-I (8-37) (mouse, rat), Calcitonin Gene-Related Peptide I (8-37) (mouse, rat)
Molecular Formula
C₁₃₈H₂₂₄N₄₂O₄₁
Relative Molecular Mass
3127.56
CAS Registry Number
129121-73-9
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
CGRP antagonist
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