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4034542

Availability: In stock

BQ-610
Azepane-1-carbonyl-Leu-D-Trp(For)-D-Trp-OH

4034542

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4034542.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 95.00
CHF 88.35 (7%)
4034542.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 158.00
CHF 146.94 (7%)

Details

BQ-610 is a very potent ET-A receptor antagonist which is about 30000 times more selective for ET-A receptors than for ET-B receptors. Furthermore, it has been found that BQ-610 strongly antagonizes ET-1 induced concentration in porcine coronary artery with a pA₂ value of 8.2.
Catalog Number H-4914
APC Number 88-2-32
Molecular Formula C₃₆H₄₄N₆O₆
Relative Molecular Mass 656.78
CAS Registry Number 141595-53-1
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Endothelin antagonist. BQ610 binds to the ET-A receptor with IC₅₀ 20 nM.
Application Cardiovascular System & Diseases
Links / Documents:

Bachem product citations

I.Drygiannakis et al., J. Crohns Colitis, 7, 286 (2013)
G.Prasanna et al., Invest. Ophthalmol. Vis. Sci., 43, 2704 (2002)

Product citations

P.T.Nowicki and L.A.Minnich, Am. J. Physiol., 276, G341 (1999)
R.J.Johnson et al., J. Pharmacol. Exp. Ther., 289, 762 (1999)
A.Caligiuri et al., Am. J. Physiol., 275, G835 (1998)
C.A.Nankervis and C.E.Miller, Am. J. Physiol., 274, G694 (1998)
J.E.Mogford et al., J. Clin. Invest., 100, 1647 (1997)
K.Ishikawa et al., Peptides 1992, Proceedings of the 22nd European Peptide Symposium, Interlaken, Switzerland, p. 685, C.H.Schneider and A.N.Eberle, eds., Escom, Leiden, (1993)