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Details
Proadrenomedullin, the precursor of adrenomedullin, contains a unique 20-residue sequence termed proadrenomedullin NH₂-terminal 20 peptide (PAMP). The i.v. administration of PAMP produces a rapid and strong hypotensive effect in anesthetized rats. It has been suggested, that PAMP functions as an inhibitory modulator of renal noradrenergic neurotransmission and plays an important role in regulating renal functions. Furthermore, it has been suggested that PAMP can act as an inhibitory regulator of adrenal catecholamine release in vivo and has a potent hyperglycemic effect after intra-third cerebroventricular administration in fasted mice.
Catalog Number
H-4916
APC Number
22-1-19
One Letter Code
ARLDVASEFRKKWNKWALSR-NH₂
Synonyms
PAMP, Pro-Adrenomedullin N-20, human
Molecular Formula
C₁₁₂H₁₇₈N₃₆O₂₇
Relative Molecular Mass
2460.87
CAS Registry Number
150238-87-2
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Cardiovascular System & Diseases
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