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This anti-opiate neuropeptide has been implicated in pain modulation as well as in opioid tolerance and may play a critical role in this process. For the neuropeptide Y-like human orphan G protein-coupled receptor HLWAR77 this peptide exhibited an EC₅₀ value of 0.39 nM. Furthermore, it has been shown to modulate a variety of physiological processes such as food intake, insulin release, blood pressure regulation and electrolyte balance. Please see also also our anorexigenic Y₁ receptor ligand BIBP3226 (E-3620).
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