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Details
The flow of information from calcium-mobilizing receptors to nuclear factor of activated T cells (NFAT)-dependent genes is critically dependent on interaction between the phosphatase calcineurin and the transcription factor NFAT. The high-affinity calcineurin-binding peptide potently inhibited NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells, without affecting the expression of other cytokines that require calcineurin but not NFAT. NFAT inhibitors may be useful in treating chronic ailments such as myocardial hypertrophy, allergy, arthritis, and autoimmune disease.
Catalog Number
H-4874
One Letter Code
MAGPHPVIVITGPHEE
Molecular Formula
C₇₅H₁₁₈N₂₀O₂₂S
Relative Molecular Mass
1683.95
CAS Registry Number
[249537-73-3] net
Source
Synthetic
Storage Conditions
-20 ± 5 °C
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