Return to Previous Page
Details
This fluorescent (FRET) peptide substrate contains the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Mca-SEVNLDAEFRK(Dnp)RR-amide has been used for assaying β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). The results suggested that TOP is a potential β-secretase candidate and is involved in the processing of APP in vivo.
Catalog Number
M-2465
APC Number
81-3-30
Synonyms
Mca-(Asn⁶⁷⁰,Leu⁶⁷¹)-APP₇₇₀ (667-676)-Lys(Dnp)-Arg-Arg amide
Molecular Formula
C₈₆H₁₂₅N₂₇O₂₉
Relative Molecular Mass
2001.10
CAS Registry Number
438625-61-7
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Alzheimer's Disease
Links / Documents:
Brochures:
Bachem product citations
Product citations
4033760
Enzyme | Substrates | Inhibitors |
---|---|---|
Thimet Oligopeptidase | ||
β-Secretase |