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4033760

Availability: In stock

Mca-(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-676)-Lys(Dnp)-Arg-Arg amide trifluoroacetate salt
Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH₂ trifluoroacetate salt

4033760

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4033760.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 473.00
CHF 439.89 (7%)
4033760.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,891.00
CHF 1,758.63 (7%)

Details

This fluorescent (FRET) peptide substrate contains the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Mca-SEVNLDAEFRK(Dnp)RR-amide has been used for assaying β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). The results suggested that TOP is a potential β-secretase candidate and is involved in the processing of APP in vivo.
Catalog Number M-2465
APC Number 81-3-30
Synonyms Mca-(Asn⁶⁷⁰,Leu⁶⁷¹)-APP₇₇₀ (667-676)-Lys(Dnp)-Arg-Arg amide
Molecular Formula C₈₆H₁₂₅N₂₇O₂₉
Relative Molecular Mass 2001.10
CAS Registry Number [438625-61-7] net
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease
Links / Documents:
Brochures:

Bachem product citations

A.M.Beckmann et al., Biol. Chem., 397, 777 (2016)
S.Ben Halima et al., Cell Rep., 14, 2127 (2016)
F.J.Rombouts et al., J. Med. Chem., 58, 8216 (2015)
H.J.Cho et al., FASEB J., 23, 2639 (2009)
H.J.Cho et al., Aging Cell, 7, 137 (2008)

Product citations

H.Koike et al., J. Biochem., 126, 235 (1999)

4033760

Enzyme Substrates Inhibitors
Thimet Oligopeptidase    
β-Secretase