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Details
Fluorogenic (FRET) substrate for pro-memapsin-2 containing the β-secretase site EVNLDAEF of the Swedish mutation of APP. The kinetic parameters at pH 4.5 are Km = 5.4 µM and kcat = 0.24 min⁻¹.
Catalog Number
M-2470
APC Number
81-3-20
Synonyms
Arg-Glu(EDANS)-(Asn⁶⁷⁰,Leu⁶⁷¹)-APP₇₇₀ (668-675)-Lys(DABCYL)-Arg
Molecular Formula
C₉₁H₁₂₉N₂₅O₂₅S
Relative Molecular Mass
2005.25
CAS Registry Number
310427-94-2
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Alzheimer's Disease
Links / Documents:
Brochures:
Bachem product citations
M.Funicello and I.Cerminara,
Medicinal chemistry,
(2016)
Product citations
A.K.Ghosh et al.,
J. Am. Chem. Soc.,
122,
3522 (2000)
4033536
Enzyme | Substrates | Inhibitors |
---|---|---|
β-Secretase |