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4033536

Availability: In stock

Arg-Glu(EDANS)-(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (668-675)-Lys(DABCYL)-Arg trifluoroacetate salt
H-Arg-Glu(EDANS)-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(DABCYL)-Arg-OH trifluoroacetate salt

4033536

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4033536.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 420.00
CHF 390.60 (7%)
4033536.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,681.00
CHF 1,563.33 (7%)

Details

Fluorogenic (FRET) substrate for pro-memapsin-2 containing the β-secretase site EVNLDAEF of the Swedish mutation of APP. The kinetic parameters at pH 4.5 are Km = 5.4 µM and kcat = 0.24 min⁻¹.
Catalog Number M-2470
APC Number 81-3-20
Synonyms Arg-Glu(EDANS)-(Asn⁶⁷⁰,Leu⁶⁷¹)-APP₇₇₀ (668-675)-Lys(DABCYL)-Arg
Molecular Formula C₉₁H₁₂₉N₂₅O₂₅S
Relative Molecular Mass 2005.25
CAS Registry Number [310427-94-2] net
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease
Links / Documents:
Brochures:

Bachem product citations

M.Funicello and I.Cerminara, Medicinal chemistry, (2016)
M.Congreve et al., J. Med. Chem., 50, 1124 (2007)
C.W.Murray et al., J. Med. Chem., 50, 1116 (2007)

Product citations

A.K.Ghosh et al., J. Am. Chem. Soc., 122, 3522 (2000)
J.Ermolieff et al., Biochemistry, 39, 12450 (2000)

4033536

Enzyme Substrates Inhibitors
β-Secretase