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Details
Ac-Tle-Tle-Asn(Me)₂-Ala-AMC is the shortest human cytomegalovirus (HCMV) protease substrate to date. It displayed excellent kinetic properties with kcat and Km values of 0.035 s⁻¹ and 13.2 µM, respectively. The resultant specificity constant kcat/Km of 2650 M⁻¹ s⁻¹ was 10-fold greater than for the non-improved substrate Abz-Val-Val-Asn-Ala-Ser-Ser-Arg-Leu-3-nitro-Tyr-Arg-OH.
Catalog Number
I-1870
Synonyms
Ac-Tle-Tle-Asn(Me)₂-Ala-AMC
Molecular Formula
C₃₃H₅₀N₆O₈
Relative Molecular Mass
658.79
CAS Registry Number
[204909-38-6]
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
HCMV substrate
Areas of Interest
Virology
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Product citations
S.R.LaPlante et al.,
J. Am. Chem. Soc.,
121,
2974 (1999)
