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Details
This member of the galanin family has been isolated from porcine hypothalamus. It is a 60 amino acid peptide that, unlike galanin, has a non-amidated C-terminus. GALP amino acid residues (9-21) are identical to the biologically active N-terminal (1-13) portion of galanin. Receptor binding studies revealed that GALP had a high affinity for the galanin receptor 2 (GALR2; IC₅₀ = 0.24 nM) and a lower affinity for the GALR1 receptor (IC₅₀ = 4.3 nM). GALP is therefore an endogenous ligand that preferentially binds the GALR2 receptor, whereas galanin is relatively non-selective.
Catalog Number
H-4982
One Letter Code
APVHRGRGGWTLNSAGYLLGPVLHPPSRAEGGGKGKTALGILDLWKAIDGLPYPQSQLAS
Synonyms
GALP (porcine)
Molecular Formula
C₂₈₁H₄₄₃N₈₁O₇₈
Relative Molecular Mass
6204.11
CAS Registry Number
[245114-96-9] net
Source
Synthetic
Storage Conditions
-20 ± 5 °C
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