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Glucagon is a 29 amino acid containing peptide hormone processed from proglucagon. As a counterregulatory hormone for insulin, glucagon plays a critical role in maintaining glucose homeostasis in vivo in both animals and humans. Not surprisingly, glucagon and glucagon receptor have been pursued extensively as potential targets for the therapeutic treatment of diabetes.
As Aβ peptides and IAPP, glucacon tends to form gel-like fibrillar aggregates. These fibrils were found to be toxic through the activation of apoptotic signaling pathways. Hence the aggregation behavior of glucagon has been studied extensively.
As Aβ peptides and IAPP, glucacon tends to form gel-like fibrillar aggregates. These fibrils were found to be toxic through the activation of apoptotic signaling pathways. Hence the aggregation behavior of glucagon has been studied extensively.
Catalog Number
H-6790
One Letter Code
HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
Synonyms
Glucagon, human
Molecular Formula
C₁₅₃H₂₂₅N₄₃O₄₉S
Relative Molecular Mass
3482.80
CAS Registry Number
[16941-32-5] net
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Areas of Interest
Diabetes
Veterinary Medicine
Veterinary Medicine
Links / Documents:
Brochures:
Bachem product citations
M.J.Bak et al.,
J. Endocrinol. Diabetes,
1,
5 (2014)
