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Details
A trademark of Merck KGaA, Darmstadt, Germany
PyBOP is a well-established, effective coupling reagent. It has been developed to replace BOP which generates the carcinogenic HMPT as a by-product during coupling. Contrary to activation with uronium/aminium-type coupling reagents, by-products resulting from guanidinylation of the amino group cannot be formed. PyBOP has been used as well for obtaining peptide thioesters.
PyBOP is a well-established, effective coupling reagent. It has been developed to replace BOP which generates the carcinogenic HMPT as a by-product during coupling. Contrary to activation with uronium/aminium-type coupling reagents, by-products resulting from guanidinylation of the amino group cannot be formed. PyBOP has been used as well for obtaining peptide thioesters.
Catalog Number
Q-2715
Molecular Formula
C₁₈H₂₈N₆OP · PF₆
Relative Molecular Mass
520.40
CAS Registry Number
[128625-52-5]
Storage Conditions
+5 ± 3 °C
Links / Documents:
Brochures:
Bachem product citations
Product citations
R.von Eggelkraut-Gottanka et al.,
Tetrahedron Lett.,
44,
3551 (2002)
J.Coste et al.,
Tetrahedron Lett.,
31,
205 (1990)
