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Details
Tertiapin (TPN), a potent inhibitor of the inward-rectifier K⁺ channels, blocked a G-protein-gated channel (GIRK1/4) and the ROMK1 channel with nanomolar affinities, however a closely related channel, IRK1, was insensitive to tertiapin. Thus, tertiapin will be a powerful ligand for purifying functional channels as well as for screening pharmaceutical agents against these channels.
Catalog Number
N-1745
One Letter Code
ALCNCNRIIIPHMCWKKCGKK -NH₂
Molecular Formula
C₁₀₆H₁₇₆N₃₄O₂₃S₅
Relative Molecular Mass
2455.11
CAS Registry Number
58694-52-3
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Channel-blocking peptide from bee venom
Application
Ion Channel Modulating Agents
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