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Details
This substance P analog is a very potent broad-spectrum neuropeptide inhibitor for small cell lung cancer (SCLC) cell growth in vitro (IC₅₀ = 5 µM). Moreover it potently inhibited signal transduction pathways in vitro and significantly delayed the growth of an SCLC xenograft in vivo. It could therefore be of therapeutic value in SCLC.
Catalog Number
H-3992
APC Number
70-9-19
One Letter Code
rPKPwQwFwLL-NH₂
Synonyms
[DArg1, DTrp5,7,9, Leu11] Substance P
Molecular Formula
C₈₁H₁₁₀N₂₀O₁₂
Relative Molecular Mass
1555.89
CAS Registry Number
[122481-75-8]
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Areas of Interest
Cancer Research
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