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4031292

Availability: In stock

(D-Arg¹,D-Trp⁵·⁷·⁹,Leu¹¹)-Substance P
H-D-Arg-Pro-Lys-Pro-D-Trp-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH₂

4031292

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4031292.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 189.00
CHF 175.77 (7%)

Details

This substance P analog is a very potent broad-spectrum neuropeptide inhibitor for small cell lung cancer (SCLC) cell growth in vitro (IC₅₀ = 5 µM). Moreover it potently inhibited signal transduction pathways in vitro and significantly delayed the growth of an SCLC xenograft in vivo. It could therefore be of therapeutic value in SCLC.
Catalog Number H-3992
APC Number 70-9-19
One Letter Code rPKPwQwFwLL-NH₂
Synonyms [DArg1, DTrp5,7,9, Leu11] Substance P
Molecular Formula C₈₁H₁₁₀N₂₀O₁₂
Relative Molecular Mass 1555.89
CAS Registry Number 122481-75-8
Source Synthetic
Storage Conditions -20 ± 5 °C
Application Cancer Research
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Product citations

S.Guha et al., Cancer Res., 65, 2738 (2005)
M.J.Seckl et al., Cancer Res., 57, 51 (1997)
M.J.Seckl et al., J. Biol. Chem., 271, 29453 (1996)