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Details
Cloning and expression of a functional human thrombin receptor have revealed a protein with seven transmembrane domains and a large extracellular amino-terminal extension. Thrombin cleaves within this extension, thereby creating a new receptor amino-terminus that functions as a tethered ligand and activates the receptor. A 14-amino acid peptide mimicking this new amino-terminus has been found to be a potent thrombin receptor activator as well as an effective agonist for platelet activation.
Catalog Number
H-8105
APC Number
82-8-25
One Letter Code
SFLLRNPNDKYEPF
Synonyms
Proteinase Activated Receptor 1 (1-14) (human), PAR-1 (1-14) (human), Thrombin Receptor Activator Peptide 14, Thrombin Related Peptide, Thrombin Receptor (1-14) (human), Coagulation Factor II Receptor (1-14) (human)
Molecular Formula
C₈₁H₁₁₈N₂₀O₂₃
Relative Molecular Mass
1739.95
CAS Registry Number
137339-65-2
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Cardiovascular System & Diseases
Hematology
Hematology
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