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Availability: In stock

(Lys⁸-psi(CH₂NH)Lys⁹)-Neurotensin (8-13)


Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4031111.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 757.00
CHF 704.01 (7%)
4031111.0025 25 mg Request lead time  
CHF 3,025.00
CHF 2,813.25 (7%)


Replacement of the Lys⁸-Lys⁹ peptide bond by the CH₂NH bond produced an analog with quite interesting pharmacological properties. The degradation-resistant peptide analog Lys-psi(CH2NH)Lys-Pro-Tyr-Ile-Leu (JMV-449) was the most active in the binding and biological assays. JMV-449 exhibited higher binding and biological potencies than neurotensin. JMV449 was also about 10 times more potent than neurotensin (8-13) in the bioassay, whereas both peptides were equipotent in the binding assay.
Catalog Number H-8370
APC Number 62-1-65
Synonyms (Lys8-acetyl-Lys9)-Neurotensin (8-13), JMV 449
Molecular Formula C₃₈H₆₆N₈O₇
Relative Molecular Mass 746.99
CAS Registry Number 139026-66-7
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Cancer Research

Product citations

L.C.Litwin and J.M.Goldstein, Drug Dev. Res., 32, 6 (1994)