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Details
PACAP-38 and its N-terminal fragment PACAP-27 are neuropeptides originally isolated from ovine hypothalamus, but also found in humans and rats. Both PACAP-27, which shows considerable homology with vasoactive intestinal polypeptide (VIP), and PACAP-38 stimulate adenylate cyclase much more potently than VIP. Specific PACAP receptors have been identified in different tissues and cell lines.Kojro et al. observed that the PAC1 agonists PACAP-27 and PACAP-38 strongly increased the activity of α-secretase, thus promoting the non-amyloidogenic processing of amyloid precursor protein.
Catalog Number
H-1172
APC Number
34-0-40
One Letter Code
HSDGIFTDSYSRYRKQMAVKKYLAAVL-NH₂
Synonyms
Pituitary Adenylate Cyclase Activating Polypeptide-27 (human, mouse, ovine, porcine, rat), PACAP-38 (1-27) amide (human, mouse, ovine, porcine, rat)
Molecular Formula
C₁₄₂H₂₂₄N₄₀O₃₉S
Relative Molecular Mass
3147.65
CAS Registry Number
127317-03-7
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Pituitary & Hypothalamic Hormones
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