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Details
Margatoxin (MgTX), originally isolated from the venom of the scorpion Centruroides margaritatus, is a peptidyl inhibitor of voltage dependent K⁺ channels in brain synaptic plasma membranes. MgTX blocks the n-type current of human T-lymphocytes (IC₅₀ = 50 pM, 20 fold more potent than charybdotoxin), has a lower dissociation rate and has no effect on Ca²⁺ activated channels. MgTX is therefore a useful tool to study the physiologic role of K⁺ channels.
Catalog Number
H-2192
One Letter Code
TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH
Molecular Formula
C₁₇₈H₂₈₆N₅₂O₅₀S₇
Relative Molecular Mass
4179.01
CAS Registry Number
[145808-47-5]
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Areas of Interest
Ion Channel Modulating Agents
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