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H-Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His-OH (Disulfide bonds between Cys⁷ and Cys²⁹/Cys¹³ and Cys³⁴/Cys¹⁷ and Cys³⁶)


Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4030845.0100 0.1 mg Ships within 3-5 business days  
CHF 473.00
CHF 439.89 (7%)
4030845.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,419.00
CHF 1,319.67 (7%)
4030845.1000 1 mg Ships within 3-5 business days  
CHF 2,521.00
CHF 2,344.53 (7%)


Margatoxin (MgTX), originally isolated from the venom of the scorpion Centruroides margaritatus, is a peptidyl inhibitor of voltage dependent K⁺ channels in brain synaptic plasma membranes. MgTX blocks the n-type current of human T-lymphocytes (IC₅₀ = 50 pM, 20 fold more potent than charybdotoxin), has a lower dissociation rate and has no effect on Ca²⁺ activated channels. MgTX is therefore a useful tool to study the physiologic role of K⁺ channels.
Catalog Number H-2192
Molecular Formula C₁₇₈H₂₈₆N₅₂O₅₀S₇
Relative Molecular Mass 4179.01
CAS Registry Number 145808-47-5
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Ion Channel Modulating Agents