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Details
This hexapeptide FRET substrate is derived from the p24/p15 cleavage site of the viral gag-pol poly-protein. A simple, continuous fluorometric assay for HIV protease has been developed, which allows the screening of potential HIV protease inhibitors.
Values for Km (2.1 μM) and kcat (7.4 s⁻¹) were calculated from steady-state data at a low concentration of the enzyme. Excitation at 280 nm, emission at > 435 nm.
Values for Km (2.1 μM) and kcat (7.4 s⁻¹) were calculated from steady-state data at a low concentration of the enzyme. Excitation at 280 nm, emission at > 435 nm.
Catalog Number
H-2992
Molecular Formula
C₄₃H₆₅N₁₃O₁₁
Relative Molecular Mass
940.07
CAS Registry Number
[133233-38-2] net
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
HIV protease FRET substrate
Areas of Interest
Infectious Disease
Links / Documents:
Brochures:
No brochures found.
Bachem product citations
C.Bonini et al.,
Tetrahedron,
61,
6580 (2005)
F.Benedetti et al.,
Arkivoc,
XIV,
140 (2003)
4030748
| Enzyme | Substrates | Inhibitors |
|---|---|---|
| Retropepsin |
