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4030716

Availability: In stock

DABCYL-γ-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS trifluoroacetate salt

4030716

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4030716.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 315.00
CHF 292.95 (7%)
4030716.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,261.00
CHF 1,172.73 (7%)

Details

The fluorogenic HIV-1 protease substrate DABCYL-Gaba-SQNYPIVQ-EDANS consists of an octapeptide with a fluorescent donor (EDANS) and a quenching acceptor (DABCYL), attached at the COOH- and NH₂-termini. The γ-Abu spacer was inserted to avoid potential steric hindrance of substrate binding by the bulky acceptor. This FRET substrate is cleaved by the HIV-1 protease at the Tyr-Pro bond which results in a time-dependent increase in fluorescence intensity; excitation at 340 nm, emission at 490 nm.
Catalog Number M-1865
APC Number 72-3-30
One Letter Code DABCYL-Gaba-SQNYPIVQ-EDANS
Molecular Formula C₇₃H₉₇N₁₇O₁₈S
Relative Molecular Mass 1532.74
CAS Registry Number 127134-13-8
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords HIV protease FRET substrate
Application Infectious Disease
Links / Documents:

Bachem product citations

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Product citations

L.Bannwarth et al., J. Med. Chem., 49, 4657 (2006)
U.Nillroth et al., Antimicrob. Agents Chemother., 41, 2383 (1997)
M.W.Pennington et al., Peptides 1992, Proceedings of the 22nd European Peptide Symposium, Interlaken, Switzerland, p. 936, C.H.Schneider and A.N.Eberle, eds., Escom, Leiden, (1993)
E.D.Matayoshi et al., Science, 247, 954 (1990)

4030716

Enzyme Substrates Inhibitors
Retropepsin    
HIV-2 Protease