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Details
M40, a peptide containing the N-terminal galanin sequence (1-13), is an antagonist of the galanin receptor. M40 significantly antagonized galanin-induced feeding behavior at doses approximately equimolar to the active doses of rat galanin. M40 inhibited the binding of (¹²⁵I-Tyr²⁶)-galanin (porcine) in rat hypothalamic membranes with an IC₅₀ value of 15 nM.
Coadministration of M40 with a muscarinic M1 agonist may enhance the efficacy of cholinergic treatments for the cognitive deficits of Alzheimer disease.
Catalog Number
H-2576
APC Number
46-1-19
One Letter Code
GWTLNSAGYLLGPPPALALA-NH₂
Synonyms
M40
Molecular Formula
C₉₄H₁₄₅N₂₃O₂₄
Relative Molecular Mass
1981.33
CAS Registry Number
143896-17-7
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Galanin antagonist
Application
Alzheimer's Disease
Obesity Research
Obesity Research
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