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Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price
4030542.0005 5 mg Request lead time  
CHF 263.00
CHF 244.59 (7%)
4030542.0025 25 mg Request lead time  
CHF 1,051.00
CHF 977.43 (7%)


In an approach to optimize substrate specificity, two amino acids have been substituted at the cleavage site of the collagenase substrate, Dnp-Pro-Leu-Gly-Leu-Trp-Ala-D-Arg-NH₂. The substrate possesses a 10-fold better kcat/Km value for human fibroblast collagenase than the FRET substrate Dnp-PLGLWAr-amide. However, monitoring of the enzyme activity using Dnp-PLGC(Me)HAr-amide requires HPLC analysis as the quencher (Trp) has been removed by the amino acid substitutions.
Catalog Number M-1905
APC Number 81-7-73
One Letter Code Dnp- PLGC(Me)HAr -NH₂
Synonyms MMP-1 Substrate II
Molecular Formula C₃₈H₅₇N₁₅O₁₁S
Relative Molecular Mass 932.03
CAS Registry Number 145224-98-2
Source Synthetic
Storage Conditions -20 ± 5 °C


Enzyme Substrates Inhibitors
Interstitial Collagenase    
Matrix Metalloproteinase-1 (MMP-1)