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4030332

Availability: In stock

Amyloid β-Protein (10-20)
H-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-OH

4030332

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
4030332.0001 1 mg Request lead time  
CHF 79.00
CHF 73.47 (7%)
4030332.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 315.00
CHF 292.95 (7%)
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Details

The amyloid precursor protein (APP) is cleaved within the amyloid β-protein region by a putative APP secretase to release its extracellular portion. Gelatinase A, the matrix metalloproteinase MMP-2, possesses such APP secretase-like activity, effectively hydrolyzing also the synthetic amyloid β-protein fragment (10-20) YEVHHQKLVFF at the normal processing site, the Lys¹⁶-Leu¹⁷ bond (Km approx. 0.13 mM).
Catalog Number H-1388
APC Number 62-0-20
One Letter Code YEVHHQKLVFF
Synonyms β-Amyloid (10-20)
Molecular Formula C₇₁H₉₉N₁₇O₁₆
Relative Molecular Mass 1446.67
CAS Registry Number [152286-31-2]
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease
Links / Documents:
Brochures:

Bachem product citations

M.Britschgi et al., Proc. Natl. Acad. Sci. USA, 106, 12145 (2009)
R.Liu et al., J. Neurosci. Res., 75, 162 (2004)

Product citations

K.Miyazaki et al., Nature, 362, 839 (1993)

4030332

Enzyme Substrates Inhibitors
Matrix Metalloproteinase-2 (MMP-2)