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Details
The amyloid precursor protein (APP) is cleaved within the amyloid β-protein region by a putative APP secretase to release its extracellular portion. Gelatinase A, the matrix metalloproteinase MMP-2, possesses such APP secretase-like activity, effectively hydrolyzing also the synthetic amyloid β-protein fragment (10-20) YEVHHQKLVFF at the normal processing site, the Lys¹⁶-Leu¹⁷ bond (Km approx. 0.13 mM).
Catalog Number
H-1388
APC Number
62-0-20
One Letter Code
YEVHHQKLVFF
Synonyms
β-Amyloid (10-20)
Molecular Formula
C₇₁H₉₉N₁₇O₁₆
Relative Molecular Mass
1446.67
CAS Registry Number
152286-31-2
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Alzheimer's Disease
Links / Documents:
Bachem product citations
Product citations
4030332
Enzyme | Substrates | Inhibitors |
---|---|---|
Matrix Metalloproteinase-2 (MMP-2) |