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4030300

Availability: In stock

Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH₂ trifluoroacetate salt

4030300

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4030300.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,366.00
CHF 1,270.38 (7%)

Details

Ac-ED(edans)KPILFFRLGK(dabcyl)E-amide, a sensitive fluorescent (FRET) peptide substrate for cathepsin D. This enzyme can degrade extracellular matrix components and may facilitate the spread of tumor cells. High levels of active cathepsin D were found within senile plaques in brains of Alzheimer's patients.
Catalog Number M-2295
Molecular Formula C₁₀₄H₁₄₆N₂₄O₂₃S
Relative Molecular Mass 2132.52
CAS Registry Number 400716-78-1
Source Synthetic
Storage Conditions -20 ± 5 °C
Application Cancer Research
Links / Documents:

Bachem product citations

S.Desmarais et al., Mol. Pharmacol., 73, 147 (2008)
S.Dandache et al., Antimicrob. Agents Chemother., 51, 4036 (2007)

Product citations

S.V.Gulnik et al., FEBS Lett., 413, 379 (1997)

4030300

Enzyme Substrates Inhibitors
Cathepsin D