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Details
The small molecule RGD peptidomimetic αvβ3 integrin antagonist XJ-735 contains both anionic and cationic binding sites that straddle the RGD binding domain of the αvβ3 integrin. The IC₅₀ values of XJ 735 for αvβ3-mediated inhibition of human and porcine cell adhesion, and vascular smooth muscle cell migration, ranged from 0.6 to 4.4 µM. In contrast, IC₅₀ for porcine or human αIIb/β3, α4β1, αvβ5, and α5β1 inhibition exceeded 100 µM.
Catalog Number
H-4772
Synonyms
XJ735
Molecular Formula
C₂₃H₃₂N₈O₇
Relative Molecular Mass
532.56
CAS Registry Number
153381-95-4
Source
Synthetic
Storage Conditions
-20 ± 5 °C
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