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Details
DEPBT, a crystalline phosphonium-type coupling reagent, mediates amide bond formation with a remarkable resistance to racemization. Thus, DEPBT is an excellent activation reagent for coupling the racemization-prone Fmoc-His(Trt)-OH. The use of DEPBT permitted the total synthesis of the antiviral peptide antibiotic feglymycin, which contains a high proportion of ring-substituted phenylglycines.
Catalog Number
Q-2565
Molecular Formula
C₁₁H₁₄N₃O₅P
Relative Molecular Mass
299.22
CAS Registry Number
[165534-43-0]
Storage Conditions
-20 ± 5 °C
Links / Documents:
Brochures:
Product citations
M.Mergler et al.,
Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries, 7th International Symposium, Southampton, p. 235, R.Epton, ed., Mayflower Worldwide,
(2002)
C.-X.Fan et al.,
Synth. Commun.,
26,
1455 (1996)
