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Details
The pyroglutamyl form of apelin-13 exhibited a high activity with an EC₅₀ value of 0.30 nM. pERPRLSHKGPMPF is probably the final product of the post-translational modification of apelin and the biologically active endogenous ligand. (Pyr¹)-Apelin-13 has been identified as the predominant apelin isoform in the human heart.
Pyr-Apelin-13 stimulates glucose utilization in normal and obese insulin-resistant mice. It could be required for the maintenance of insulin sensitivity.
Pyr-Apelin-13 stimulates glucose utilization in normal and obese insulin-resistant mice. It could be required for the maintenance of insulin sensitivity.
Catalog Number
H-4568
APC Number
12-1-16
One Letter Code
pERPRLSHKGPMPF
Synonyms
(Glp1)-Apelin-13, human, bovine
Molecular Formula
C₆₉H₁₀₈N₂₂O₁₆S
Relative Molecular Mass
1533.82
CAS Registry Number
[217082-60-5]
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Final product of apelin metabolization; Mediator of vasodilation
Areas of Interest
Diabetes
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