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Details
The N-terminal elongation of the widely used MMP FRET substrate Mca-PLGL-Dpa-AR-NH₂ (M-1895) with a Lys yields a fluorogenic peptide with improved substrate properties. As compared to M-1895, the specificity constant (kcat/Km) of the broad-spectrum MMP-substrate M-2350, Mca-KPLGL-Dpa-AR-NH₂ for collagenases (MMP-1, MMP-8, MMP-13) and MMP-14 is increased two- to ninefold and threefold, respectively, while those for gelatinases and matrilysin remain equally high.
Catalog Number
M-2350
One Letter Code
Mca-KPLGL-Dpa-AR-NH₂
Molecular Formula
C₅₅H₈₀N₁₆O₁₆
Relative Molecular Mass
1221.34
CAS Registry Number
[720710-69-0] net
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Areas of Interest
Cancer Research
Inflammation Research
Inflammation Research
Links / Documents:
Brochures:
Bachem product citations
4028885
| Enzyme | Substrates | Inhibitors |
|---|---|---|
| Interstitial Collagenase | ||
| Gelatinase A | ||
| Stromelysin 1 | ||
| Matrilysin | ||
| Collagenase-2 | ||
| Gelatinase B | ||
| Collagenase-3 | ||
| Matrix Metalloproteinase-14 (MMP-14) | ||
| Matrix Metalloproteinase-2 (MMP-2) | ||
| Matrix Metalloproteinase-1 (MMP-1) | ||
| Matrix Metalloproteinase-7 (MMP-7) | ||
| Matrix Metalloproteinase-3 (MMP-3) | ||
| Matrix Metalloproteinase-8 (MMP-8) | ||
| Matrix Metalloproteinase-9 (MMP-9) | ||
| Matrix Metalloproteinase-13 (MMP-13) | ||
| Matrix Metalloproteinase-20 (MMP-20) | ||
| ADAM17 Endopeptidase |
