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4028885

Availability: In stock

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH₂ trifluoroacetate salt

4028885

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
4028885.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 294.00
CHF 273.42 (7%)
4028885.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,177.00
CHF 1,094.61 (7%)
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Details

The N-terminal elongation of the widely used MMP FRET substrate Mca-PLGL-Dpa-AR-NH₂ (M-1895) with a Lys yields a fluorogenic peptide with improved substrate properties. As compared to M-1895, the specificity constant (kcat/Km) of the broad-spectrum MMP-substrate M-2350, Mca-KPLGL-Dpa-AR-NH₂ for collagenases (MMP-1, MMP-8, MMP-13) and MMP-14 is increased two- to ninefold and threefold, respectively, while those for gelatinases and matrilysin remain equally high.
Catalog Number M-2350
One Letter Code Mca-KPLGL-Dpa-AR-NH₂
Molecular Formula C₅₅H₈₀N₁₆O₁₆
Relative Molecular Mass 1221.34
CAS Registry Number [720710-69-0] net
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Cancer Research
Inflammation Research
Links / Documents:
Brochures:

Bachem product citations

E.Nuti et al., ChemMedChem, 11, 1626 (2016)
S.Sjoli et al., Eur. J. Med. Chem., 108, 141 (2016)
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M.R.Zocchi et al., Oncoiummunology, 5, e1123367 (2016)
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F.Casalini et al., J. Med. Chem., 56, 2676 (2013)
M.Giustiniano et al., J. Amino Acids, 2013, 178381 (2013)
F.Heus et al., Toxicon, 61, 112 (2013)
S.M.Marques et al., J. Inorg. Biochem., 127, 188 (2013)
L.Devy et al., Cancer Res., 69, 1517 (2009)
M.T.Rubino et al., ChemMedChem, 4, 352 (2009)
P.Geurink et al., Org. Biomol. Chem., 6, 1244 (2008)
K.Tanimoto et al., J. Dent. Res., 87, 451 (2008)
K.Tanimoto et al., J. Dent. Res., 87, 451 (2008)
E.Huet et al., Biochem. Pharmacol., 67, 643 (2004)
U.Neumann et al., Anal. Biochem., 328, 166 (2004)
U.Neumann et al., Anal. Biochem., 328, 166 (2004)

Product citations

K.Tanimoto et al., J. Dent. Res., 87, 451 (2008)
M.O.Palmier and S.R.Van Doren, Anal. Biochem., 371, 43 (2007)
U.Neumann et al., Anal. Biochem., 328, 166 (2004)

4028885

Enzyme Substrates Inhibitors
Interstitial Collagenase    
Gelatinase A    
Stromelysin 1    
Matrilysin    
Collagenase-2    
Gelatinase B    
Collagenase-3    
Matrix Metalloproteinase-14 (MMP-14)    
Matrix Metalloproteinase-2 (MMP-2)    
Matrix Metalloproteinase-1 (MMP-1)    
Matrix Metalloproteinase-7 (MMP-7)    
Matrix Metalloproteinase-3 (MMP-3)    
Matrix Metalloproteinase-8 (MMP-8)    
Matrix Metalloproteinase-9 (MMP-9)    
Matrix Metalloproteinase-13 (MMP-13)    
Matrix Metalloproteinase-20 (MMP-20)    
ADAM17 Endopeptidase