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4028885

Availability: In stock

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH₂ trifluoroacetate salt

4028885

Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4028885.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 294.00
CHF 273.42 (7%)
4028885.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,177.00
CHF 1,094.61 (7%)

Details

The N-terminal elongation of the widely used MMP FRET substrate Mca-PLGL-Dpa-AR-NH₂ with a Lys yields a fluorogenic peptide with improved substrate properties. As compared to Mca-PLGL-Dpa-AR-NH₂, the specificity constant (kcat/Km) of the broad-spectrum MMP-substrate Mca-KPLGL-Dpa-AR-NH₂ for collagenases (MMP-1, MMP-8, MMP-13) and MMP-14 is increased two- to ninefold and threefold, respectively, while those for gelatinases and matrilysin remain equally high.
Catalog Number M-2350
One Letter Code Mca-KPLGL-Dpa-AR-NH₂
Molecular Formula C₅₅H₈₀N₁₆O₁₆
Relative Molecular Mass 1221.34
CAS Registry Number 720710-69-0
Source Synthetic
Storage Conditions -20 ± 5 °C
Application Cancer Research
Inflammation Research
Links / Documents:

Bachem product citations

D.Zimmermann et al., Plant Physiol., 171, 1456 (2016)
E.Nuti et al., ChemMedChem, 11, 1626 (2016)
M.R.Zocchi et al., Oncoiummunology, 5, e1123367 (2016)
S.Sjoli et al., Eur. J. Med. Chem., 108, 141 (2016)
E.Nuti et al., J. Med. Chem., 58, 7224 (2015)
F.Heus et al., Biology (Basel), 3, 139 (2014)
F.Casalini et al., J. Med. Chem., 56, 2676 (2013)
F.Heus et al., Toxicon, 61, 112 (2013)
M.Giustiniano et al., J. Amino Acids, 2013, 178381 (2013)
S.M.Marques et al., J. Inorg. Biochem., 127, 188 (2013)
L.Devy et al., Cancer Res., 69, 1517 (2009)
M.T.Rubino et al., ChemMedChem, 4, 352 (2009)
K.Tanimoto et al., J. Dent. Res., 87, 451 (2008)
K.Tanimoto et al., J. Dent. Res., 87, 451 (2008)
P.Geurink et al., Org. Biomol. Chem., 6, 1244 (2008)
E.Huet et al., Biochem. Pharmacol., 67, 643 (2004)
U.Neumann et al., Anal. Biochem., 328, 166 (2004)
U.Neumann et al., Anal. Biochem., 328, 166 (2004)

Product citations

K.Tanimoto et al., J. Dent. Res., 87, 451 (2008)
M.O.Palmier and S.R.Van Doren, Anal. Biochem., 371, 43 (2007)
U.Neumann et al., Anal. Biochem., 328, 166 (2004)

4028885

Enzyme Substrates Inhibitors
Interstitial Collagenase    
Gelatinase A    
Stromelysin 1    
Matrilysin    
Collagenase-2    
Gelatinase B    
Collagenase-3    
Matrix Metalloproteinase-14 (MMP-14)    
Matrix Metalloproteinase-2 (MMP-2)    
Matrix Metalloproteinase-1 (MMP-1)    
Matrix Metalloproteinase-7 (MMP-7)    
Matrix Metalloproteinase-3 (MMP-3)    
Matrix Metalloproteinase-8 (MMP-8)    
Matrix Metalloproteinase-9 (MMP-9)    
Matrix Metalloproteinase-13 (MMP-13)    
Matrix Metalloproteinase-20 (MMP-20)    
ADAM17 Endopeptidase