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Details
NBD-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys(DMC)-NH₂ (NBD-RPKPLA-Nva-WK(DMC) amide) is an excellent fluorogenic substrate for hydrolysis of the matrix metalloproteinase stromelysin (MMP-3). This FRET substrate exhibits high sensitivity and improves accuracy at lower substrate turnover. It has a kcat/Km value of 2.14 x 10⁴ M⁻¹s⁻¹ and can be easily detected at 350 nm (excitation) and 465 nm (emission). Therefore this compound is a suitable tool for high-throughput inhibitor screening.
Catalog Number
M-2300
Synonyms
NBD-ε-aminocaproyl-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys(DMACA)-NH₂
Molecular Formula
C₇₈H₁₁₁N₂₁O₁₆
Relative Molecular Mass
1598.87
CAS Registry Number
945414-97-1
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Application
Cancer Research
Inflammation Research
Inflammation Research
Links / Documents:
Bachem product citations
4028275
Enzyme | Substrates | Inhibitors |
---|---|---|
Stromelysin 1 | ||
Matrix Metalloproteinase-3 (MMP-3) |