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Product No. Pack Size Available ADS InfoAnalytical Data Sheet List Price Online Order Price Qty
4028110.0500 0.5 mg Ships within 3-5 business days  
CHF 589.00
CHF 547.77 (7%)
4028110.1000 1 mg Ships within 3-5 business days  
CHF 1,051.00
CHF 977.43 (7%)


AF12198 exhibited both in vitro and in vivo IL-1 antagonist activity. It selectively bound the human type I IL-1 receptor but not the human type II receptor or the murine type I receptor. In vitro, AF12198 inhibited IL-1-induced IL-8 production by human dermal fibroblasts with an IC₅₀ of 25 nM and IL-1-induced intercellular adhesion molecule-1 expression by endothelial cells with an IC₅₀ of 9 nM. In vivo it blocked ex-vivo IL-1 induction of IL-6 and down modulates in vivo induction of IL-6. This is the first small molecule which shows IL-1 receptor antagonist activity in vivo.
Catalog Number H-4146
One Letter Code Ac-FEWTPGWYQ-Aze-YALPL-NH₂
Synonyms AF12198
Molecular Formula C₉₆H₁₂₃N₁₉O₂₂
Relative Molecular Mass 1895.15
CAS Registry Number 185413-30-3
Source Synthetic
Storage Conditions -20 ± 5 °C