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Details
CA-074Me, the membrane-permeant prodrug of CA-074, represents a proinhibitor, that itself is almost inactive, but can enter cells and there inhibit intracellular cathepsin B. Therefore CA-074Me is suggested to be a very promising reagent for the investigation of the intracellular functions of cathepsin B. This cysteine protease showing β-secretase activity could be involved in amyloid β formation.
Catalog Number
N-1660
Synonyms
CA-074Me, N-(L-3-trans-(Propylamino)carbonyl)-oxirane-2-carbonyl)-Ile-Pro-OMe, L-trans-Epoxysuccinyl(propylamide)-Ile-Pro-OMe
Molecular Formula
C₁₉H₃₁N₃O₆
Relative Molecular Mass
397.47
CAS Registry Number
147859-80-1
Source
Synthetic
Storage Conditions
-20 ± 5 °C
Keywords
Cell-permeable cathepsin B inhibitor
Links / Documents:
Bachem product citations
A.Bervar et al.,
Radiology and oncology,
2,
169 (2002)
4027913
| Enzyme | Substrates | Inhibitors |
|---|---|---|
| Cathepsin B | ||
| Cathepsin B |
