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Details
The inhibitor E64c, which contains 3-methylbutylamine instead of agmatine, was found to react with the essential thiol groups of papain which led to a loss of activity. The compound corresponding to the acid of loxistatin (E64d) was also shown to inhibit cathepsins B and L more rapidly than E64.
Catalog Number
N-1655
Synonyms
E-64c, EP 475
Molecular Formula
C₁₅H₂₆N₂O₅
Relative Molecular Mass
314.38
CAS Registry Number
[76684-89-4]
Storage Conditions
-20 ± 5 °C
Keywords
Cys proteinase inhibitor
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Bachem product citations
4027912
| Enzyme | Substrates | Inhibitors |
|---|---|---|
| Cathepsin B | ||
| Cathepsin H | ||
| Cathepsin L | ||
| Cathepsin S | ||
| Calpain |
